Negrini is an Italian surname. Notable people with the surname include:
Alessandra Negrini (born 1970), Brazilian actress Antonio Negrini (1903–1994), Italian cyclist Carlo Negrini (1826–1865), Italian opera singer Chiara Negrini (born 1979), Italian volleyball player Clare Negrini Claudiomiro Negrini (born 1967), Brazilian footballer Gualtiero Negrini (born 1961), American opera singer Luciano Negrini (1920–2012), Italian rower Matteo Negrini (born 1982), Italian footballer Vincenzo Negrini (1804–1840), Italian opera singer
See also Nigrini