Brushy Creek is a stream in northwest Henry County in the U.S. state of Missouri. It is a tributary of Big Creek.
The headwaters arise about two miles northeast of Creighton (at ) and the stream flows to the east-northeast about three miles. The confluence with Big Creek is about 1.5 miles south of Blairstown (at ).Blairstown, Missouri, and Quick City, Missouri, 7.5 Minute Topographic Quadrangles, USGS, 1955-6
Brushy Creek was so named on account of brush lining its course.
See also List of rivers of Missouri
References