Pfefferle is a surname of South German origin. The word is a diminutive of pfeffer, and identifies a person who sells spices.
Notable people with the surname Pfefferle Gérald Pfefferle (born 1960), a Swiss fencer Markus Pfefferle, a German paralympic gold medalist in alpine skiing William C. Pfefferle (1923–2010), an American scientist and inventor W.T. Pfefferle (born 1962), a Canadian poet
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