Odhiambo is a surname. Notable people with the surname include:
Agnes Odhiambo (accountant), Kenyan accountant and civil servant Agnes Odhiambo (activist), Kenyan human rights activist who works at Human Rights Watch Alfred Odhiambo, Kenyan politician Bernard Odhiambo, Kenyan footballer Billy Odhiambo (born 1993), Kenyan rugby sevens player David Odhiambo (born 1976), Kenyan cricket umpire Eisha Stephen Atieno Odhiambo (1945–2009), Kenyan academic Eric Odhiambo (born 1989), English footballer Kennedy Odhiambo, Kenyan footballer Moses Odhiambo (born 1986), Kenyan footballer Nehemiah Odhiambo (born 1984), Kenyan cricketer Nelson Odhiambo (born 1989), Kenyan cricketer Okot Odhiambo, also known as Two Victor, his radio call sign, a senior leader of the Lord's Resistance Army, a Ugandan rebel group Peter Amollo Odhiambo, Kenyan consultant thoracic and cardiovascular surgeon Peter Odhiambo (born 1966), Kenyan boxer Rees Odhiambo (born 1992), American football player in the NFL Sunday Odhiambo, Kenyan footballer Sylvester Odhiambo, Kenyan association football coach Thomas R. Odhiambo (1931–2003), Kenyan entomologist and environmental activist