Cole Creek is a stream in northern Gasconade County in the U.S. state of Missouri. It is a tributary of the Missouri River.
The stream headwaters arise about one mile east of Gasconade and about one mile south of the Missouri River at . The stream flows to the northeast for about two miles roughly parallel to the Missouri. It then turns north to its confluence with the Missouri at two miles west of Hermann.Missouri Atlas & Gazetteer, DeLorme, 1998, First edition, p. 39
The namesake of Cole Creek is unknown.
See also List of rivers of Missouri
References