Spring Creek is a stream in southeastern Franklin County in the U.S. state of Missouri. It is a tributary of Bourbeuse River.

The stream headwaters arise along the north side of Missouri Route 185 approximately one mile west of downtown Sullivan at .Sullivan, MO, 7.5 Minute Topographic Quadrangle, USGS, 1969 (1980 rev.) The stream flows north passing west of the Long Ridge Conservation Area three miles east of Spring Bluff. It turns northeast to its confluence with the Bourbeuse at approximately four miles north of Stanton. The stream gains the water of two named springs, Sour Spring west of the conservation area and Kratz Spring north of the conservation area.Spring Bluff, MO, 7.5 Minute Topographic Quadrangle, USGS, 1966 (1980 rev.)

Spring Creek was named for the fact its flow is increased by springs along its course.

See also List of rivers of Missouri

References