Margarita Ortega may refer to:
Margarita Ortega (actress) (Margarita Ortega Cadavid, born 1973), Colombian television presenter and actress Margarita Ortega (magonist) (Margarita Ortega Valdés, 1871–1913), Mexican anarchist revolutionary Margarita Ortega Villa (1951–1996), Mexican politician from Baja California