Mohamed Khalifa may refer to:
Mohamed Abdel Aziz Khalifa (born 1925), Egyptian swimmer Mohamed Asswai Khalifa (born 1944), Libyan hurdler Mohamed Khalifa (footballer) (born 1986), Egyptian footballer Mohamed Khalifa (shot putter) (born 1996), Egyptian shot putter Mohamed Ould Khalifa (born 1968), Mauritanian long-distance runner Mohammed Jamal Khalifa (1957–2007), Saudi businessman Mohammed Khalifa, Canadian ISIS member