Perilli is an Italian surname. Notable people with the surname include:
Alessandra Perilli (born 1988), Sammarinese sport shooter Alessio Perilli (1983–2004), Italian motorcycle racer Arianna Perilli (born 1978), Sammarinese sport shooter Frank Ray Perilli (1925–2018), American screenwriter, playwright and actor Ivo Perilli (1902–1994), Italian screenwriter Lorenzo Perilli, Italian classicist and academic Simone Perilli (born 1995), Italian footballer