Speakes is an English surname. It may refer to:
People Larry Speakes (1939–2014), an acting press spokesman for the White House under President Reagan Stephen M. Speakes (b. 1952), a United States Army lieutenant general
Fictional characters The Speakeses, a family in the soap opera Guiding Light, including Hampton (Vince Williams), Kathryn (Nia Long) and Gilly Speakes (Amelia Marshall).