Mofokeng is a South African surname. It may refer to the following notable people:
Gabriel Mofokeng (born 1982), South African footballer George Mofokeng (born 1979), South African long-distance runner George Mofokeng (born 1979), South African footballer Jerry Mofokeng (born 1956), South African actor Lethola Mofokeng (born 1984), South African footballer Mandla Mofokeng (born 1967), South African musician Relebohile Mofokeng (born 2004), South African football player Ryder Mofokeng (born 1950), South African footballer and football manager Sammy Mofokeng (born 1991), South African cricketer Santu Mofokeng (1956–2020), South African photographer Tlaleng Mofokeng, South African physician