Gwathmey is a surname. Notable people with the surname include:
Charles Gwathmey (1938–2009), American architect James Tayloe Gwathmey (1862–1944), American physician Robert Gwathmey (1903–1988), American painter Rosalie Gwathmey (1908–2001), American photographer
Other Gwathmey Siegel & Associates Architects, US-based architectural firm