Rastelli is an Italian surname. Notable people with the surname include:
Ellis Rastelli (born 1975), Italian cyclist Enrico Rastelli (1896–1931), Italian juggler, acrobat and performer Giancarlo Rastelli (1934–1970), Italian cardiac surgeon Rastelli procedure, an open heart surgical procedure Maicol Rastelli (born 1991), Italian cross-country skier Massimo Rastelli (born 1968), Italian footballer and manager Philip Rastelli (1918–1991), American mobster