Tickle is an English toponymic surname, derived from Tickhill in Yorkshire. Notable people with the surname include:
Charlie Tickle (1883 – after 1919), English footballer Cheryll Tickle, British biologist Danny Tickle (born 1983), English rugby league footballer David Tickle, British record producer and engineer Gerard William Tickle (1909–1994), English prelate Jon Tickle (born 1974), British TV presenter Phyllis Tickle (1934–2015), American author and lecturer Sam Tickle (born 2002), English professional footballer Steven Ray Tickle, American television personality on Moonshiners and Tickle.
See also Tickle (disambiguation) Mr. Tickle, the first book in the Mr. Men series by Roger Hargreaves Tickell