Zacher is a German surname. Notable people with the surname include:
Daniel Zacher (born 1988), German footballer Elmer Zacher (1880–1944), American baseball player Gábor Zacher (born 1960), Hungarian physician Gerd Zacher (1929–2014), German composer, organist and writer Hans F. Zacher (1928–2015), German academician Heidi Zacher, German freestyle skier Johann Michael Zächer (1649–1712), Austrian composer Julius Zacher (1816–1887), German philologist Rolf Zacher (1941–2018), German actor