Saco River may refer to:
Saco River, a river in northeastern New Hampshire and southwestern Maine in the United States East Branch Saco River, a river in the White Mountains of New Hampshire, a tributary of the Saco River East Fork East Branch Saco River, a tributary of the East Branch of the Saco River Little Saco River, a tributary of the Saco River in western Maine Old Course Saco River, a river in western Maine, the route of the Saco River until the early 1800s Saco River (Maranhão), a river of Maranhão state in northeastern Brazil Saco River (Paracauari), a river in the state of Pará, Brazil, a left tributary of the Paracauari River Do Saco River (Rio de Janeiro), a river of Rio de Janeiro state in southeastern Brazil
See also Sacco (river), a river in Italy