Eisele is a German surname. Notable people with the surname include:
Alois Eisele (1914–2008), German Wehrmacht officer Carolyn Eisele (1902–2000), American mathematician Donn F. Eisele (1930–1987), American astronaut Garnett Thomas Eisele (1923–2017), American judge George Raymond Eisele (1923–1942), United States Naval Reserve sailor Hans Eisele (disambiguation), multiple people John Eisele (1884–1933), American middle-distance runner Joseph Eisele (1834–1868), German serial killer
See also USS Eisele