Santi Giacomo e Niccolò is a Roman Catholic parish church in the village of Quercegrossa, within the municipal limits of Castelnuovo Berardenga, a few kilometers outside of Siena, region of Tuscany, Italy.

History The church was originally ancient, built in romanesque-style, but has undergone numerous reconstructions, including major ones in the early 19th century, and in 1957. Traces of the romanesque structure remain on the left side. Once serving a parish church, since 2011 services have mainly transferred to a new parish church. The church still houses a late 15th-century polychrome sculptural group of the Pietà, a masterwork of Francesco di Giorgio Martini, likely assisted by . The work was brought here from the now-razed Olivetan monastery of San Benedetto fuori Porta Tufi in Siena.Luoghi della Fede in Toscana website.

An inventory in 1840 also noted the presence of altarpieces depicting San Giacomo by Martelli, a Madonna by Matteo de Giovanni (possibly Matteo Giovanetti), and a processional standard by likely Annibale Mazzuoli.Cenni storico-artistici di Siena e suoi suburbii, by Ettore Romagnoli, (1840) page 66.

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