Denezhkin (masculine, Russian: Денезхин, Ukrainian: Денезхін) or Denezhkina (feminine, Russian: Денезхина, Ukrainian: Денезхіна) is a Russian and Ukrainian surname. Notable people with the surname include:

Alexander Denezhkin (born 1991), Russian ice hockey player Irina Denezhkina (born 1981), Russian writer

See also Denezhkin Kamen Nature Reserve in Russia