Protein FAM241B is a protein that in humans is encoded by the gene FAM241B (previously C10orf35). Not much is reported about the protein, but it is predicted to be a transmembrane protein. The protein contains the domain of unknown function 4605 (DUF4605) which belongs to the protein family pfam15378.
General characteristics The physical properties of the c10orf35 protein were analyzed, and the molecular weight was predicted to be 13.2 kdal, and the isoelectric point was predicted to be 11.5. The properties of DUF4605 were also analyzed, and the molecular weight was predicted to be 6.0 kdal. The isoelectric point was predicted to be 6.9, which is significantly less basic than the full protein.
Properties and structure
DUF 4605 is located between amino acids 62 and 92. The secondary structure of the c10orf35 protein was predicted to consist of a β-sheet between amino acids 3 and 5, an α-helix between 61 and 72, and a transmembrane α-helix between 92 and 112. The serine in position 62 can be phosphorylated to form a phosphoserine group.
Expression
The c10orf35 protein has expression over the 75th percentile in the brain, spinal cord, and male reproductive organs. Within the male reproductive system, the RNA is found within the testis and prostate, while the protein is expressed in the epididymis. In the brain, the RNA is found in the cerebral cortex, while the protein is expressed ubiquitously throughout the brain.
Protein interactions The c10orf35 protein has been experimentally shown by Affinity Capture-MS to interact with 7 other proteins as shown below. Interacting Protein Symbol Definition ATP1B3 ATPase, Na+/K+ Transporting, Beta 3 Polypeptide CD3E CD3e molecule, epsilon (CD3-TCR complex) GABRE Gamma-aminobutyric acid (GABA) A receptor, epsilon HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic LPAR1 Lysophosphatidic acid receptor 1 SGCD Sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) ZACN Zinc activated ligand-gated ion channel
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