Casalegno is a family name of Italian origin. Notable people with the surname include:
Carlo Casalegno (1916–1977), Italian journalist and writer Elenoire Casalegno (born 1976), Italian television presenter Gabriele Casalegno (born 1923), Italian rugby player Gavin Casalegno, (born 1999), American actor Jacqueline Casalegno (1926–2019), French businesswoman Mattia Casalegno (born 1981), Italian artist