Coppolino is an Italian surname. Notable people with the surname include:
Andrea Coppolino (born 1979), Italian artistic gymnast Carl A. Coppolino (1933 – after 1979), American murderer Eric Francis Coppolino (born 1964), American journalist Matthew Coppolino (1929–2000), American politician Nadia Bartel, née Coppolino (born 1985), Australian model