Birnie is a surname. Notable people with the surname include:
Alexander Birnie, (1763–1835), Scottish merchant and shipowner David and Catherine Birnie, Australian husband and wife pair of serial killers Esmond Birnie (born 1965), author, economist, and Ulster Unionist Party politician George Birnie Esslemont (1860–1917), British Liberal politician Harry Charles Birnie (1882–1943), Scottish seaman, captain with the Cunard line and commodore in the Royal Navy Reserve James Birnie (1799–1864), Scottish fur trader in the Pacific Northwest John Birnie Philip (1824–1875), English sculptor of the 19th century Patricia Birnie (1926–2013), British lawyer Ted Birnie (1878–1935), professional footballer and manager Tessa Birnie (1934–2008), New Zealand-born Australian concert pianist William Birnie Rhind (1853–1933), Scottish sculptor