Domingues is a Portuguese surname. Its Spanish variant is Domínguez. Notable people with the surname include:
Adauto Domingues (born 1961), Brazilian middle-distance runner Adelina Domingues (1888–2002), American supercentenarian Altino Domingues (born 1951), Portuguese-American football player Amy Domingues, American cellist and viola da gamba player Diana Domingues (1947–2025), Brazilian artist and art historian Ivan Domingues (born 2006), Portuguese racing driver João Domingues (born 1993), Portuguese tennis player Leandro Domingues (1983–2025), Brazilian footballer Maurício Rodrigues Alves Domingues (born 1978), Brazilian football player Nicholas Domingues (born 1992), South African Roller hockey player Rachel Domingues (born 2006), Canadian-Portuguese actor Renan Cardoso Domingues (born 1988), Brazilian football player
See also Domingues (born 1983), Mozambican footballer