Two-time defending champion Novak Djokovic defeated Kei Nishikori in the final, 6–3, 6–3 to win the men's singles tennis title at the 2016 Miami Open. Djokovic completed his record fourth Sunshine Double with the win, and won his record-equaling sixth Miami Open title (tied with Andre Agassi). It was also his third consecutive Sunshine Double. He did not lose a single set in the entire tournament.
For the first time in tournament history, no Americans reached the last-of-16 stage.
Seeds All seeds receive a bye into the second round.
Draw
Finals
Top half
Section 1
Section 2
Section 3
Section 4
Bottom half
Section 5
Section 6
Section 7
Section 8
Qualifying
Seeds
Qualifiers
Lucky losers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
Eighth qualifier
Ninth qualifier
Tenth qualifier
Eleventh qualifier
Twelfth qualifier
External links Main draw Qualifying draw