James Burke may refer to:

Politics James F. Burke (politician) (1867–1932), United States Representative from Pennsylvania James Burke (Australian politician) (born 1971), member of the Northern Territory Legislative Assembly James Burke (Cork politician) (died 1936), Irish Cumann na nGaedhael politician and barrister James Burke (Roscommon politician) (died 1964), Irish Fine Gael politician and farmer James A. Burke (New York politician) (1890–1965), New York City politician and Queens Borough President James A. Burke (Massachusetts politician) (1910–1983), U.S. congressman from Massachusetts James Edmund Burke (1849–1943), American politician and mayor of Burlington, Vermont

Sports James Burke (boxer) (1809–1845), English boxer James Burke (cricketer) (born 1991), English cricketer James Burke (19th-century footballer), 19th-century football player James Burke (Dublin hurler), inter county senior hurler with Dublin James Burke (Kildare hurler) (born 1999), Irish hurler James Burke (wrestler) (1936–2006), American Olympic wrestler Jamie Burke (born 1971), baseball player Jamie Burke (rugby union) (born 1980), American rugby union player James Burke (baseball), American baseball player for the 1884 Boston Reds Jimmy Burke (baseball) (1874–1942), American baseball player

Other fields James Burke (bishop) (1926–1994), American-born Catholic bishop in Peru James Burke (science historian) (born 1936), British broadcaster, author, and television producer James E. Burke (1925–2012), CEO of Johnson & Johnson James Cobb Burke (1915–1964), American photographer and photojournalist James Burke (actor) (1886–1968), appeared in The Maltese Falcon and numerous other films James Lee Burke (born 1936), American author James Burke (gangster) (1931–1996), Irish-American gangster E. James Burke (born 1949), justice of the Wyoming Supreme Court James Burke (space engineer) (1925–2023), American lunar settlement and exploration expert, known for the Ranger program James F. Burke (musician) (1923–1981), American cornet soloist James Burke (police officer), police chief in Suffolk County, New York James Wakefield Burke (1906–1989), American journalist and writer

See also James Burk (born 1948), sociologist and professor of sociology at Texas A&M University Jim Burke (disambiguation) Jimmy Burke (disambiguation)