Descalzi is an Italian surname. It is pronounced . Notable people with the surname include:
Cayetano Descalzi (born Gaetano Descalzi) (1809–1886), Italian painter and engraver active in Argentina Claudio Descalzi (born 1955), Italian businessman in the energy sector Giuseppe Gaetano Descalzi (1767-1855), Genoese furniture maker Nicolás Descalzi, the namesake of Nicolás Descalzi in Buenos Aires, Argentina