This list of people in Playboy 2000–2009 is a catalog of women and men who appeared in Playboy magazine between the years 2000 and 2009, inclusive. Not all of the people featured on the cover or in the magazine model in the nude.

Entries in blue indicate that the issue marks the original appearance of that year's Playmate of the Year (PMOY).

2000 Month Cover model Centerfold model Interview subject 20 Questions Pictorials January Peter Max cover art Carol Bernaola and Darlene Bernaola Hugh Hefner Rupert Everett Verne Troyer as 'Mini-Hef' February Angie Everhart Suzanne Stokes Jeff Bezos Steven Van Zandt Angie Everhart March Caprice Bourret Nicole Marie Lenz Jon Stewart Cindy Margolis Caprice April Bijou Phillips Brande Roderick Rowland Evans & Robert Novak Barry White Bijou Phillips May Sandy Bentley, Mandy Bentley (alternate Canadian cover featured Samantha Speer) Brooke Berry Pete Rose Michael Palin Sandy and Mandy Bentley June Jodi Ann Paterson Shannon Stewart Trey Parker & Matt Stone James Coburn Carré Otis, Jodi Ann Paterson – PMOY July Jaime Bergman Neferteri Shepherd George Clooney Carson Daly Jaime Bergman August Darva Conger Summer Altice John Malkovich Aimee Mann Darva Conger, Dorothy Stratten September Shari Belafonte Kerissa Fare Jennifer Lopez Seth Green Shari Belafonte, Sherry Lynne White October Lauren Michelle Hill Nichole Van Croft Bob Costas Michael Johnson College Girls of Conference USA November Chyna Buffy Tyler Ben Stiller Neil LaBute Chyna December Carmen Electra Cara Michelle Drew Barrymore Jakob Dylan Carmen Electra

2001 Month Cover model Centerfold model Interview subject 20 Questions Pictorials January Gabrielle Reece Irina Voronina Gary Johnson Carol Alt Gabrielle Reece February Anna Nicole Smith Lauren Michelle Hill Vince McMahon Sela Ward Anna Nicole Smith [reruns and outtakes from June 1993], surfer Amy Cobb March Kylie Bax Miriam Gonzalez Bobby Knight Traci Lords Kylie Bax April Irina Voronina Katie Lohmann Metallica Wyclef Jean May Brooke Burke Crista Nicole Tom Green Mariska Hargitay Brooke Burke, Temptation Island's Lola Corwin June Brande Roderick Heather Spytek Charlie Sheen Edward Burns Brande Roderick – PMOY July Pamela Anderson Kimberley Stanfield Chris Matthews Johnny Knoxville Pamela Anderson, police officer Ginger Harrisson August Belinda Carlisle Jennifer Walcott Tim Burton Jon Bon Jovi Belinda Carlisle September Jerri Manthey Dalene Kurtis Dale Earnhardt Jr. Stanley Tucci Jerri Manthey, Vampirella model Sascha Knopf October Julia Schultz, Stephanie Heinrich, Nicole Lenz Stephanie Heinrich cast of The West Wing: Martin Sheen, Rob Lowe, Aaron Sorkin, John Wells, Thomas Schlamme, Pat Caddell, John Spencer, Bradley Whitford, Janel Moloney, Allison Janney, Richard Schiff and Dulé Hill Marg Helgenberger Track athlete Leilani Rios, College Girls of the Southeastern Conference November Angelica Bridges Lindsey Vuolo Coen Brothers Will Ferrell Angelica Bridges December Gena Lee Nolin Shanna Moakler Will Smith Catherine Bell Gena Lee Nolin, Bebe Buell

2002 Month Cover model Centerfold model Interview subject 20 Questions Pictorials January Chyna Nicole Narain Brit Hume Dan Patrick Joanie Laurer February Dedee Pfeiffer Anka Romensky Gary Hart Hugh Jackman Dedee Pfeiffer March Kira Kener, Dasha, Tera Patrick Tina Marie Jordan Allen Iverson Jamie Foxx boxer Amy Hayes April Tiffany Heather Carolin Lennox Lewis Sarah Silverman Tiffany May Kiana Tom Christi Shake Bill O'Reilly Milla Jovovich Kiana Tom June Dalene Kurtis Michele Rogers Curt Schilling Oscar De La Hoya Dalene Kurtis – PMOY July Shallan Meiers, Christina Santiago, Lauren Anderson Lauren Anderson Fred Durst Chris Isaak Adriana Karembeu August Christine Nielsen Christina Santiago Harrison Ford Amanda Peet Rosie and Renee Tenison September Jordan Shallan Meiers Larry Ellison Lenny Kravitz Jordan, Anita Marks October Teri Marie Harrison Teri Marie Harrison Al Michaels Jamie Oliver College Girls of the Big 12 November Kristy Swanson Serria Tawan Willie Nelson Marshall Faulk Kristy Swanson December Dita Von Teese Lani Todd Denzel Washington Greg Kinnear Dita Von Teese

2003 Month Cover model Centerfold model Interview subject 20 Questions Pictorials January Tia Carrere Rebecca Anne Ramos Halle Berry Ron Insana Tia Carrere February Alison Eastwood Charis Boyle Jimmy Kimmel Bernie Mac Allison Eastwood, Tila Tequila March Dorismar Pennelope Jimenez Colin Farrell Juliette Lewis spy Katrina Barellova April Carmen Electra Carmella DeCesare Jay-Z Andy Richter Carmen Electra May Torrie Wilson Laurie Fetter Billy Bob Thornton Jorja Fox Torrie Wilson June Sarah Kozer Tailor James Mike Piazza Nelly Sarah Kozer, PMOY Christina Santiago July Nikki Ziering Markéta Jánská Lisa Marie Presley Rachel Weisz Nikki Ziering August Jenna Morasca, Heidi Strobel Colleen Marie Tobey Maguire Charles Rangel Jenna Morasca and Heidi Strobel, Carnie Wilson September Signe Nordli Luci Victoria Jon Gruden Nicolas Cage Jenny Haase, Women of Starbucks October Lauren Michelle Hill Audra Lynn O. J. Simpson Joe Rogan Deanna Merryman, College Girls of the Big Ten November Daryl Hannah Divini Rae Quentin Tarantino Bill Murray Daryl Hannah December Shannen Doherty Deisy Teles and Sarah Teles John Cusack William H. Macy Shannen Doherty

2004 Month Cover model Centerfold model Interview subject 20 Questions Pictorials January none Colleen Shannon Jack Nicholson Al Franken February Jaime Pressly Aliya Wolf Kiefer Sutherland Dave Matthews Jaime Pressly March Sable, Torrie Wilson (two alternative covers) Sandra Hubby Jim Carrey William Petersen Sable, Torrie Wilson April Rachel Hunter Krista Kelly 50 Cent Kevin Smith Rachel Hunter May Pamela Anderson Nicole Whitehead Johnny Depp Matthew Perry Pamela Anderson June Charisma Carpenter Hiromi Oshima Derek Jeter Jude Law Charisma Carpenter, PMOY Carmella DeCesare July Peta Wilson Stephanie Glasson Michael Moore Christina Applegate Peta Wilson August Eva Herzigova Pilar Lastra Matt Damon Spike Lee Eva Herzigova September Amy Acuff Scarlett Keegan Sergey Brin & Larry Page Terrell Owens October Evelyn Gery Kimberly Holland Donald Trump Jimmy Fallon November Brooke Burke Cara Zavaleta Oliver Stone John Carmack Brooke Burke, Kari Ann Peniche, College Girls of the Atlantic Coast Conference December Denise Richards Tiffany Fallon Bernie Mac Dustin Hoffman Denise Richards

2005 Month Cover model Centerfold model Interview subject 20 Questions Pictorials January Jenny McCarthy Destiny Davis Toby Keith James Caan Jenny McCarthy February Teri Polo Amber Campisi Nicole Kidman Teri Polo March Paris Hilton Jillian Grace The Rock Kid Rock Debbie Gibson April Christy Hemme Courtney Rachel Culkin Les Moonves Mena Suvari Christy Hemme May Michelle Baena Jamie Westenhiser James Spader Vitali Klitschko The Amazing Race's Victoria Fuller June Bai Ling Kara Monaco Lance Armstrong Paul Giamatti Playmate of the Year Tiffany Fallon, Bai Ling July Joanna Krupa Qiana Chase Owen Wilson Scarlett Johansson Joanna Krupa, Karina Lombard August Diora Baird Tamara Witmer Ewan McGregor Kate Hudson Diora Baird September Jessica Canseco Vanessa Hoelsher Thomas L. Friedman Kurt Busch Jessica Canseco October Sara Jean Underwood (identified as Sara Jean with Victoria Thornton on the inside of the foldout cover) Amanda Paige George Carlin Ozzy Osbourne Fiona Horne, College Girls of the Pac-10 November Holly Madison, Bridget Marquardt & Kendra Wilkinson Raquel Gibson Jamie Foxx Steve Carell The Girls Next Door, Kelly Monaco December Marilyn Monroe Christine Smith Pierce Brosnan Al Pacino Rachel Veltri

2006 Month Cover model Centerfold model Interview subject 20 Questions Pictorials January Lisa Guerrero Athena Lundberg Mark Cuban Kate Beckinsale Lisa Guerrero February Adrianne Curry Cassandra Lynn Al Franken Hugh Laurie Adrianne Curry March Jessica Alba Monica Leigh Kanye West Franz Ferdinand Willa Ford April Candice Michelle Holley Ann Dorrough Keanu Reeves Craig Ferguson Candice Michelle May Alison Waite Alison Waite Ozzie Guillén Rebecca Romijn Rachel Sterling June Kara Monaco Stephanie Larimore Shepard Smith Jason Lee PMOY – Kara Monaco July Vida Guerra Sara Jean Underwood Jerry Bruckheimer Dana White Vida Guerra August Monica Leigh Nicole Voss Denis Leary Luke Wilson Stacey Dash September Kendra Wilkinson, Holly Madison & Bridget Marquardt Janine Habeck Michael D. Brown Eva Longoria The Girls Next Door, Paris Hilton impersonator Natalie Reid October Tamara Witmer Jordan Monroe Ludacris Johnny Knoxville Christine Dolce, College Girls of the Big 12 November Mercedes McNab Sarah Elizabeth Arianna Huffington Tenacious D Mercedes McNab December Cindy Margolis Kia Drayton Dixie Chicks Samuel L. Jackson Cindy Margolis, Danielle O'Hara

2007 Month Cover model Centerfold model Interview subject 20 Questions PictorialsJanuary Pamela Anderson Jayde Nicole T. Boone Pickens Ellen Pompeo Pamela AndersonFebruary Tricia Helfer Heather Rene Smith Simon Cowell Bettie Page Tricia Helfer, Michelle Manhart, Jesse JaneMarch Mariah Carey Tyran Richard Jeremy Piven Mariah Carey Erica ChevillarApril Ashley Massaro Giuliana Marino Bill Maher Will Arnett Ashley MassaroMay Anna Nicole Smith Shannon James Steve Nash Fergie Anna Nicole Smith, College Girls of Conference USAJune Kristine Lefebvre Brittany Binger Matt Groening Don Rickles PMOY – Sara Jean Underwood, Kristine LefebvreJuly Amanda Beard Tiffany Selby Bruce Willis Danica Patrick Amanda BeardAugust Garcelle Beauvais Tamara Sky Chris Tucker Paul Rudd Garcelle Beauvais-Nilon, Vicki, Sarah, and Rachel SatterfieldSeptember Amanda Paige Patrice Hollis Clive Owen Jaime Pressly Christa CampbellOctober Giuliana Marino Spencer Scott Keith Olbermann Ali Larter Alicia Machado, College Girls of the Southeastern ConferenceNovember Lindsey Roeper Lindsay Wagner Robert Redford Matt Leinart Barry Bonds' mistress Kimberly BellDecember Kim Kardashian Sasckya Porto Bill Richardson Joaquin Phoenix Kim Kardashian, Leona Rajacic

2008 Month Cover model Centerfold model Interview subject 20 Questions PictorialsJanuary Adrianne Curry Sandra Nilsson Tina Fey Helena Bonham Carter Adrianne CurryFebruary Tiffany Fallon Michelle McLaughlin Matthew McConaughey Rachel Bilson Irish McCallaMarch Kendra Wilkinson, Holly Madison & Bridget Marquardt Ida Ljungqvist Garry Kasparov Charles Barkley Coco AustinApril Maria Kanellis Regina Deutinger Chad Kroeger Jenna Fischer Maria KanellisMay Olga Kurbatova AJ Alexander Fareed Zakaria Bob Saget Women of Russia, Jennifer LeighJune Jayde Nicole Juliette Fretté Steve Carell Harvey Levin Jayde Nicole – PMOYJuly Cindy Margolis Laura Croft Drew Pinsky Lewis Black Cindy Margolis, Marilyn MonroeAugust Ashley Harkleroad Kayla Collins Ben Stiller Selma Blair Ashley Harkleroad, Susie FeldmanSeptember Anna Faris Valerie Mason Dana White Anna Faris Beauty and the Geek's Amanda Corey October Kelly Carrington Kelly Carrington Pete Wentz Kevin Connolly Kristy Morgan, College Girls of the Big TenNovember Rachelle Leah Grace Kim Daniel Craig Chelsea Handler Rachelle LeahDecember Carol Alt Jennifer and Natalie Jo Campbell Hugh Jackman Rosario Dawson Carol Alt

2009