Little Orphan Annie is the name of an American comic strip begun in 1924.

Little Orphan Annie may also refer to:

Little Orphan Annie (radio series), an American radio drama series based on the comic strip Little Orphant Annie (1918 film) Little Orphan Annie (1932 film), a 1932 American film based on the comic strip, starring Mitzi Green Little Orphan Annie (1938 film), a 1938 American film based on the comic strip, starring Ann Gillis

See also "Little Orphant Annie", an 1885 poem written by James Whitcomb Riley