Mandakini may refer to:
Ganges in Hinduism, as considered to form the Milky Way in the sky Mandakini River, Uttarakhand, India Chandragiri River, also known as Payaswini and Mandakini, a river in India Mandakini (1999 film), a Sri Lankan film Mandakini (2024 film), an Indian Malayalam film
People Mandakini (actress) (born 1963), Indian actress Mandakini Amte, Indian doctor and social worker Mandakini Behera (born 1947), Indian politician in Odisha Mandakini Gogate (1936–2010), Indian Marathi writer Mandakini Narayanan (died 2006), Indian Naxalite leader in Kerala Mandakini Trivedi, Indian dancer