MacDonough is an Irish surname, it may refer to:
Surname Elizabeth MacDonough, the current Parliamentarian of the United States Senate George MacDonough or George Macdonogh GBE KCB KCMG (1865–1942), British Army general officer Glen MacDonough (1870–1924), US American writer, lyricist and librettist Harry Macdonough (1871–1931), Canadian singer and recording executive James MacDonough (born 1970) American professional bass guitarist Thomas Macdonough (1783–1825), early-19th-century American naval officer noted for his roles in the first Barbary War and the War of 1812
Given name Macdonough Craven, (1858–1919), American naval officer, engineer, and politician Tunis Augustus Macdonough Craven (1813–1864), officer in the United States Navy
Places MacDonough, Delaware, a small unincorporated community in New Castle County, Delaware, United States MacDonough Island, a large island in the Possession Sound portion of Puget Sound, located in Island County, Washington Commodore Thomas MacDonough Highway, State Route 314 (New York–Vermont) (NY 314) and Vermont Route 314 (VT 314) Comdr. Thomas MacDonough House, a historic home located near Odessa, New Castle County, Delaware
Ships USS Macdonough (DD-331), Clemson-class destroyer built for the United States Navy during World War I USS Macdonough (DD-351), Farragut-class destroyer in the United States Navy during World War II USS Macdonough (DD-9), Lawrence-class destroyer, which was a sub-class of Bainbridge-class destroyer, in the United States Navy USS Macdonough (DDG-39), Farragut class guided missile destroyer in the United States Navy
See also McDonough