For the company, see Stefanini IT Solutions.

Stefanini is an Italian surname. Notable people with the surname include:

Antonietta Stefanini, best known as Antonella Steni (1926–2016), Italian actress, voice actress, comedian and presenter Fúlvio Stefanini (born 1939), Brazilian actor Lucrezia Stefanini (born 1998), Italian tennis player Luigi Stefanini (1891–1956), Italian philosopher Matteo Stefanini (born 1984), Italian rower Rafe Stefanini (born 1950s), Italian banjo player and guitarist