The South Atlantic–Gulf water resource region is one of 21 major geographic areas, or regions, in the first level of classification used by the United States Geological Survey to divide and subdivide the United States into successively smaller hydrologic units. These geographic areas contain either the drainage area of a major river, or the combined drainage areas of a series of rivers.

The South Atlantic–Gulf region, which is listed with a 2-digit hydrologic unit code (HUC) of 03, has an approximate size of , and consists of 18 subregions, which are listed with the 4-digit HUCs 0301 through 0318.

This region includes the drainage that ultimately discharges into: (a) the Atlantic Ocean within and between the states of Virginia and Florida; (b) the Gulf of Mexico within and between the states of Florida and Louisiana; and (c) the associated waters. The geographic area of the South Atlantic–Gulf region includes all of Florida and South Carolina, and parts of Alabama, Georgia, Louisiana, Mississippi, North Carolina, Tennessee, and Virginia.

Listing of water resource subregions Subregion HUC Subregion Name Subregion Description Subregion Location Subregion Size Subregion Map 0301 Chowan–Roanoke Subregion The coastal drainage and associated waters from and including the Back Bay drainage to Oregon Inlet. Located in Virginia and North Carolina. 0302 Neuse–Pamlico Subregion The coastal drainage and associated waters from Oregon Inlet to Browns Inlet. Located in North Carolina. 0303 Cape Fear Subregion The coastal drainage and associated waters from Browns Inlet to and including the Cape Fear River Basin. Located in North Carolina. 0304 Pee Dee Subregion The coastal drainage and associated waters from the Cape Fear River Basin boundary to the Santee River Basin boundary. Located in North Carolina, South Carolina, and Virginia. 0305 Edisto–Santee Subregion The coastal drainage and associated waters from and including the Santee River Basin to the Savannah River Basin boundary. Located in Georgia, North Carolina, and South Carolina. 0306 Ogeechee–Savannah Subregion The coastal drainage and associated waters from and including the Savannah River Basin to the Altamaha River Basin boundary. Located in Georgia, North Carolina, and South Carolina. 0307 Altamaha–St. Marys Subregion The coastal drainage and associated waters from and including the Altamaha River Basin to the St. Johns River Basin boundary. Located in Florida and Georgia. 0308 St. Johns Subregion The coastal drainage and associated waters from and including the St. Johns River Basin to St. Lucie Inlet. Located in Florida. 0309 Southern Florida Subregion The coastal drainage and associated waters from St. Lucie Inlet to and including the Caloosahatchee River Basin, and interior drainage south of the St. Johns and Peace River Basins. Located in Florida. 0310 Peace–Tampa Bay Subregion The coastal drainage and associated waters from the Caloosahatchee River Basin boundary to and including the Withlacoochee River Basin. Located in Florida. 0311 Suwannee Subregion The coastal drainage and associated waters from the Withlacoochee River Basin boundary to and including the Aucilla River Basin. Located in Florida and Georgia. 0312 Ochlockonee Subregion The coastal drainage and associated waters from the Aucilla River Basin boundary to and including the Ochlockonee River Basin. Located in Florida and Georgia. 0313 Apalachicola Subregion The coastal drainage and associated waters from the Ochlockonee River Basin boundary to and including the Apalachicola River Basin and the drainage into Apalachicola Bay. Located in Alabama, Florida, and Georgia. 0314 Choctawhatchee–Escambia Subregion The coastal drainage and associated waters from the Apalachicola Bay drainage boundary to the Mobile Bay drainage boundary. Located in Alabama and Florida. 0315 Alabama Subregion The Alabama River Basin. Located in Alabama, Georgia, and Tennessee. 0316 Mobile–Tombigbee Subregion The drainage into Mobile Bay excluding the Alabama River Basin. Located in Alabama and Mississippi. 0317 Pascagoula Subregion The coastal drainage and associated waters in Alabama and Mississippi north and east of the Louisiana-Mississippi state line from the Mobile Bay drainage boundary to the Pearl River (Mississippi–Louisiana) Basin boundary. Located in Alabama and Mississippi. 0318 Pearl Subregion The Pearl River basin. Located in Louisiana and Mississippi.

See also List of rivers in the United States Water Resource Region

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