Chen Hualan (; born March 1969) is a Chinese veterinary virologist best known for researching animal epidemic diseases. She is a member of the World Organisation for Animal Health (OIE) and a member of the Food and Agriculture Organization Corporate Statistical Database (FAOSTAT). She is now a researcher and PhD Supervisor at Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences.
She has been listed among the "Ten Scientific Figures of the Year" by Nature in 2013. She won the L'Oréal-UNESCO Awards for Women in Science in 2016, and was elected to the Chinese Academy of Sciences in 2017.
Biography Chen was born in Jingyuan County, Baiyin, Gansu province in 1969. In 1987, she was admitted to the Department of Veterinary Medicine of Gansu Agricultural University. In 1991, after receiving a bachelor's degree, she continued to major in veterinary pathology in the Department of Veterinary Medicine of Gansu Agricultural University and studied as a graduate student. In 1994, after graduating with a master's degree, she was admitted to the Graduate School of the Chinese Academy of Agricultural Sciences.
In 1997, she obtained a doctorate degree in infectious disease and preventive veterinary medicine, and then worked as an assistant researcher at the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences. In 1999, she went to the Influenza Sub-center of the Centers for Disease Control of the United States for post-doctoral work and collaborative research on bird flu.
In 2002, she returned to China and served as a researcher at the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, and successively served as the director of the Key Laboratory of Animal Influenza of the Ministry of Agriculture and the director of the National Avian Influenza Reference Laboratory.
On November 9, 2005, she won the 2nd China Young Women Scientist Award. In 2006, she won the China Youth May 4 Medal.
In 2008, she served as the director of the Avian Influenza Reference Laboratory of the World Organization for Animal Health. In 2008, she was awarded the National Science Fund for Distinguished Young Scholars. In 2009, joined the Jiu San Society.
In October 2015, she was awarded the "World Outstanding Female Scientist Achievement Award" by UNESCO-L'Oréal, and is the fifth Chinese to receive this award. In the same year, she was named one of the "Global Highly Cited Scientists" by Thomson Reuters.
In June 2016, she won the National Outstanding Science and Technology Talent Award and the China Outstanding Young Science and Technology Talent Award.
In November 2017, she was elected an academician of the Chinese Academy of Sciences.
In March 2018, she served as a member of the Agricultural and Rural Committee of the 13th National Committee of the Chinese People's Political Consultative Conference.
In November 2018, Vice Chairman (concurrently) of the All-China Women's Federation, a researcher at the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, the director of the Key Laboratory of Animal Influenza of the Ministry of Agriculture and Rural Affairs, and an academician of the Chinese Academy of Sciences.
She was a member of the 12th and 13th National Committee of the Chinese People's Political Consultative Conference.
On the afternoon of November 1, 2018, the 12th Executive Committee of the All-China Women's Federation held its first plenary meeting. Chen Hualan was elected as the vice chairman of the All-China Women's Federation.
Personal life Chen is married and has a son.
Major achievement Research Summary
Chen Hualan presided over the National Avian Influenza Reference Laboratory and systematically carried out the epidemiological monitoring and research work of avian influenza in China, and achieved a series of significant progress and creative research results, and initially clarified the molecular genetics, antigenic variation and pathogenicity of the avian influenza virus. The law of evolution provides a comprehensive scientific basis for the early warning and forecasting of the epidemic, prevention and control strategies, the development and use of diagnostic reagents and vaccines. During the prevention and control of avian influenza, the rapid and accurate diagnosis of a large number of samples from all over the country played a key role in the timely and effective control of the epidemic. It has made a significant contribution to the control of the bird flu epidemic.
Chen has led the National Avian Influenza Reference Laboratory and studied epidemiology, diagnostic technology, new vaccine development, molecular evolution and molecular pathogenic mechanism of animal influenza, especially avian influenza. The laboratory developed the H5 subtype inactivated avian influenza vaccine and the new "avian influenza and Newcastle disease recombinant dual live vaccine". These are used in the disease control of poultry in China and the world. The ability of influenza has very important socio-economic and public health significance.
In April 2013, Chen Hualan and her scientific research team discovered that the new H7N9 influenza virus that causes human infection in China is highly homologous to the H7N9 avian influenza virus that existed in the live poultry market during the same period. It is the first internationally from the perspective of etiology. The source of the new H7N9 influenza virus was revealed, which provided an important basis for the scientific prevention and control of H7N9 avian influenza in China. In May, they discovered that the H5N1 virus could indeed reassort with the human influenza virus to obtain the ability to transmit efficiently through the air between mammals, thus having the potential to cause a human pandemic, revealing the H5N1 virus from a new perspective. A real threat to global public health. In July, she and researchers found that the H7N9 virus is not pathogenic to poultry, but after the virus invades the human body and mutates, its pathogenicity and horizontal transmission ability to mammals are significantly enhanced, thus revealing the existence of H7N9 virus. The risk of a pandemic among adults. These results have been published in the English version of "Science Bulletin" and "Science (SCIENCE)" magazine.
On November 20, 2019, the Chinese Academy of Agricultural Sciences released 10 basic scientific research results that can fully represent the frontier research level of China's agricultural science and technology in 2018 and have made major breakthroughs, including: the rapid development of the H7N9 highly pathogenic avian influenza virus Evolution and its successful prevention and control. The research was led by the team of Academician Chen Hualan from the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences. Through large-scale monitoring of poultry avian influenza viruses, the H7N9 highly pathogenic avian influenza viruses were systematically studied and successfully developed H5 and H7 bivalents. The avian influenza inactivated vaccine, monitoring results showed that the vaccine effectively blocked the H7N9 virus from spreading in poultry, and it also achieved "immediate results" in blocking human infection with the H7N9 virus.
Awards First Class National Science and Technology Progress Award Second Class National Technology Invention Award Chinese Agricultural Elites Award China Youth Science and Technology Award China Young Female Scientists Award (2011) National "May 1" Labor Medal China Youth "May 4" Medal L'Oréal-UNESCO Awards for Women in Science Asian Scientist 100, Asian Scientist, 2017
Project and achievements Since 1994, Chen Hualan has been engaged in basic research and applied research related to avian influenza and swine influenza, and has presided over more than 20 scientific research projects such as national "key research", "863", "973", and the National Natural Science Foundation of China.
+ Awards Time Achievement name Awards Reference 2005 Development and application of H5 subtype avian influenza inactivated vaccine First Prize of National Science and Technology Progress Award 2007 Recombinant avian influenza and Newcastle disease combined live vaccine Second Prize of National Technological Invention 2007 Avian influenza virus evolution, cross-species infection and molecular mechanism of pathogenicity Second Prize of National Nature Award 2009 Study on the molecular mechanism of H5N1 subtype avian influenza virus evolution, cross-host infection and pathogenicity First Prize of Natural Science of Heilongjiang Province 2010 Avian influenza (H5+H9) bivalent inactivated vaccine First Prize of Heilongjiang Province Scientific Progress Award 2013 Avian influenza virus evolution, cross-species infection and molecular mechanism of pathogenicity National Natural Science Second Prize 2019 Research on Cross-species Infection and Transmission of Animal Influenza Viruses National Natural Science Second Prize
Journal Papers & Patented Inventions As of 2014, Chen Hualan has published more than 50 SCI papers related to avian influenza research in important international academic journals; he has obtained 6 new veterinary drug certificates for avian influenza vaccines, of which 3 are genetic engineering vaccines; and 7 national invention patents have been obtained
Representative articles 1. Yanbing Li, Liling Liu, Yi Zhang, Zhenhua Duan, Guobin Tian, Xianying Zeng, Jianzhong Shi, Licheng Zhang, Hualan Chen*. New lineage of H5N1 influenza virus detected in wild birds in Qinghai, western China. Emerging Infectious Disease, 2010, in press.
2. Ying Chen, Gongxun Zhong, Guojun Wang, Guohua Deng, Yanbing Li, Jianzhong Shi, Zhuo Zhang, Yuntao Guan, Yongping Jiang, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen*. Dogs are highly susceptible to H5N1 avian influenza virus. Virology. 2010, 405, 15-19, on-line, June 25.
3. Lihong Tao, Jinying Ge, Xijun Wang, Hongyue Zhai, Tao Hua, Bolin Zhao, Dongni Kong, Chinglai Yang, Hualan Chen*, and Zhigao Bu*. Molecular Basis of Neurovirulence of Flury Rabies Virus Vaccine Strains: Importance of the Polymerase and the Glycoprotein R333Q Mutation. Journal of Virology. 2010, 84 (17), 8926-8936. on-line, June 10
4. Yanbing Li, Jianzhong Shi, Gongxun Zhong, Guohua Deng, Guobin Tian, Jinying Ge, Xianying Zeng, Jiasheng Song, Dongming Zhao, Liling Liu, Yongping Jiang, Yuntao Guan, Zhigao Bu, Hualan Chen*. Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry and humans in China from 2004 to 2009. Journal of Virology. 2010, 84(17), 8389-8379. On-line, June 10.
5. Yujie Tang, Gongxun Zhong, Lianhui Zhu, Xing Liu, Yufei Shan, Huapeng Feng, Zhigao Bu, Hualan Chen*, and Chen Wang. Herc5 Attenuates Influenza A Virus by Catalyzing ISGylation of Viral NS1 Protein. Journal of Immunology, 2010, 184, 5777-5790
6. Bo Wah Leung, Hualan Chen, George G. Brownlee. Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity. Virology, 2010, 401：96-106.
7. Yuwei Gao, Ying Zhang, Kyoko Shinya, Guohua Deng, Yongping Jiang, Zejun Li, Yutao Guan, Guobin Tian, Yanbing Li, Jianzhong Shi, Liling Liu, Xianying Zeng, Zhigao Bu, Xianzhu Xia, Yoshihiro Kawaoka, Hualan Chen*. Identification of Amino Acids in HA and PB2 Critical for the Transmission of H5N1 Avian Influenza Viruses in a Mammalian Host. PLoS Pathogens, 2009, 5(12): e1000709.
8. Yongping Jiang, Hongbo Zhang, Guojun Wang, Pingjing Zhang, Guobin Tian, Zhigao Bu, and Hualan Chen*. Protective Efficacy of H7 Subtype Avian Influenza DNA Vaccine. Avian Disease, 2010, 54(S1), 294-296.
9. Jinying Ge, Guobin Tian, Xianying Zeng, Yongping Jiang, Hualan Chen and Zhigao Bu*. Generation and Evaluation of a Newcastle Disease Virus-Based H9 Avian Influenza Live Vaccine. Avian Disease, 2010, 54(S1), 290-293.