Defending champion Althea Gibson defeated Darlene Hard in the final, 3–6, 6–1, 6–2 to win the women's singles tennis title at the 1958 U.S. National Championships.

Seeds The seeded players are listed below. Althea Gibson is the champion; others show in brackets the round in which they were eliminated.

Althea Gibson (champion) Dorothy Knode (quarterfinals) Ann Haydon (third round) Maria Bueno (quarterfinals) Janet Hopps (first round) Sally Moore (quarterfinals) Christine Truman (quarterfinals) Beverly Baker Fleitz (semifinals)

Draw

Key Q = Qualifier WC = Wild card LL = Lucky loser r = Retired

Final eight

References