is a Japanese biochemist. He is known for the discovery and development of hundreds of pharmaceuticals originally occurring in microorganisms. In 2015 he shared the Nobel Prize in Physiology or Medicine with Tu Youyou and with William C. Campbell for their role in the discovery of the world's first endectocide, ivermectin, a safe and highly effective microfilaricide. It is believed that the large molecular size of ivermectin prevents it from crossing the blood/aqueous humour barrier, and renders the drug an important treatment of helminthically-derived blindness.

Early life and education Satoshi Ōmura was born in Nirasaki, Yamanashi, Japan, in 1935, the second son of Ōmura family. After graduating from the University of Yamanashi in 1958, he was appointed to science teacher at Tokyo Metropolitan Sumida Tech High School. In 1960, he became an auditor of Koji Nakanishi's course at Tokyo University of Education, one year later, he enrolled in the Tokyo University of Science (TUS) and studied sciences. Ōmura received his M.S. degree from TUS and his Ph.D. in Pharmaceutical Sciences from the University of Tokyo (1968, a Dissertation PhD) and a Ph.D. in Chemistry at TUS (1970).

Career Since 1965 Ōmura served at Kitasato Institute system.大村智北里研究所顧問・北里大学名誉教授が文化功労者に 北里大学 2012年11月1日 From 1970 to 1990, he also became a part-time lecturer at Tokyo University of Science.[from ストックホルム]「これからは人材の育成に努力します」大村先生が語った受賞後の活動 TUSToday 2015.12.18

In 1971 while he was a visiting professor at Wesleyan University, he consulted the chairman of the American Chemical Society, Max Tishler, at an international conference. Together they successfully acquired research expenses from Merck & Co.「人間発見」日本経済新聞2010年7月14日 Ōmura was considering continuing his research in the United States, but ultimately he decided to return to Japan.

In 1973, he became a director of the antibiotic laboratory at Kitasato University,「【ノーベル賞受賞】大村智氏、常識破りの発想で治療薬開発 」 産経ニュース2015.10.5 and he also started collaborative research with Merck & Co.「 新しい微生物創薬の世界を切り開く 」 JT

In 1975, he became professor of Kitasato University School of Pharmacy. Meanwhile, the Ōmura laboratory raised many researchers and produced 31 university professors and 120 doctors.

At present date, Ōmura is professor emeritus at Kitasato University and Max Tishler Professor of Chemistry at Wesleyan University. Research

Satoshi Ōmura is known for the discovery and development of various pharmaceuticals originally occurring in microorganisms. He was awarded the 2015 Nobel Prize in Physiology or Medicine jointly with William C. Campbell for discoveries concerning a novel therapy against infections caused by roundworm parasites. More precisely, his research group isolated a strain of Streptomyces avermitilis that produce the anti-parasitical compound avermectin. Campbell later acquired these bacteria and developed the derived drug ivermectin that was commercialised for veterinary use in 1981, later put to human use against Onchocerciasis in 1987–88 with the name Mectizan, and is used against river blindness, lymphatic filariasis, scabies, other parasitic infections.Press release NobelPrize.org

Since the 1970s, Ōmura has discovered more than 480 new compounds, of which 25 kinds of drugs and reagents are in use. Examples include andrastin, herbimycin, neoxaline as well as: a specific inhibitor of protein kinase named staurosporine; a proteasome inhibitor named lactacystin; a fatty acid biosynthesis inhibitor named cerulenin;

Furthermore, compounds having a unique structure and biological activity discovered by Omura are drawing attention in drug discovery research, and new anticancer drugs and the like have been created.

Selected publications

Social role Ōmura served as deputy director and director at the Kitasato Institute. He was devoted to rebuild the laboratory and promoting the establishment of the medical center that is now Kitasato University Medical Center. Meanwhile, he established a path to rebuilding of the corporate school juridical person, which has integrated with the School corporation Kitasato Gakuen. He succeeded in establishing a new "School corporation Kitasato Institute". In addition, he served as president of the School corporation Joshibi University of Art and Design twice, and served as the honorary school chief of the School corporation Kaichi Gakuen. In 2007, he established the Nirasaki Omura Art Museum on his collection.

Awards and honors

Statues of children leading adults blinded by onchocerciasis, outside Kitasato University buildings, were produced by sculptors of Burkina Faso in honor of Ōmura's invention of avermectin and ivermectin, a symbol of the campaign to eradicate onchocerciasis. Similar life-sized bronze statues were erected at World Health Organization (WHO) headquarters in Geneva, Carter Center, Merck & Co., World Bank Headquarters, and Burkina Faso's World Health Organization Africa Onchocerciasis Control Program.

1985 – Hoechst-Roussel Award 1986 – The Pharmaceutical Society of Japan Award 1988 – Uehara Prize 1990 – Japan Academy Prize (academics) 1992 – Medal with Purple Ribbon 1995 – Fujihara Award 1997 – Robert Koch Gold Medal 1998 – Prince Mahidol Award 2000 – Nakanishi Prize (American Chemical Society and Chemical Society of Japan) 2005 – Ernest Guenther Award in the Chemistry of Natural Products (American Chemical Society) 2007 – Hamao Umezawa Memorial Award 2008 – Knight of the Legion of Honour of France 2010 – Tetrahedron Prize for Creativity in Organic Chemistry 2011 – Arima Award 2011 – Order of the Sacred Treasure, Gold and Silver Star【政府】11年「春の叙勲」‐森田氏に旭重、大村氏が瑞重 薬事日報 2011年6月20日 2012 – Person of Cultural Merit 2014 – Canada Gairdner Global Health Award 2015 – Asahi Prize 2015 – The Order of Cultural Merit 2015 – Nobel Prize in Physiology or Medicine 2016 – Japan Bioindustry Association (JBA) Special Honorary Award 2016 – Society for Actinomycetes Japan (SAJ) Special Honorary Award 2016 – Asian Scientist 100, Asian Scientist

Honorary doctorates List of honorary doctorates: 1992 – Lajos Kossuth University, Hungary 1994 – Wesleyan University, USA 2016 – Shanghai Jiao Tong University, China 2018 – University of St Andrews, Scotland

Learned societies membership

1992 – Academy of Sciences Leopoldina 1999 – National Academy of Sciences 2001 – Japan Academy 2002 – Académie des sciences 2005 – Russian Academy of Sciences 2005 – Royal Society of Chemistry 2005 – Academia Europaea 2006 – Chinese Academy of Engineering 2009 – Japan Society for Bioscience, Biotechnology and Agrochemistry 2014 – 2016 – Japan Pharmaceutical Association 2016 – Japan Society of Synthetic Organic Chemistry 2016 – Japan Society of Chemotherapy

See also Lactacystin, Cerulenin, Andrastin A, Herbimycin, and Neoxaline Koji Nakanishi Tohru Fukuyama Kitasato Shibasaburō List of Japanese Nobel laureates List of Nobel laureates affiliated with the University of Tokyo

References

External links Professor Satoshi Omura Satoshi Ōmura | People | THE KITASATO INSTITUTE Nirasaki Omura Art Museum Satoshi Ōmura Quotes With Pictures