Spanos is a surname of Greek origin. Notable people with the surname include:
Alex Spanos (1923–2018), American owner of the San Diego Chargers Anthony Spanos (born 1995), Australian actor Danny Spanos, American musician Dean Spanos (born 1950), American chairman and owner of the Los Angeles Chargers Giannis Spanos (1934–2019), Greek musician John Spanos (born 1961), Australian soccer player Lou Spanos (born 1971), American football coach Matt Spanos (born 1984), American football player Nicholas Spanos (1942–1994), American/Canadian psychology professor Peter Spanos, American politician Nick Spanos (died 1990), Australian murder victim Vasili Spanos (born 1981), American baseball player William V. Spanos (1924–2017), American literature
See also Spano (disambiguation)