Orthwein is a surname. Notable people with the surname include:
Charles F. Orthwein (1839–1898), German-born American businessman. William D. Orthwein (1841–1925), German-born American businessman. Frederick C. Orthwein (1871–1927), American businessman. William R. Orthwein (1881–1955), American water polo player, attorney. Percy Orthwein (1888–1957), American businessman William R. Orthwein Jr. (1917–2011), American businessman and philanthropist. Adolphus Busch Orthwein (1917–2013), American heir and business executive James Orthwein (1924–2008), American heir and businessman Stephen A. Orthwein (1945–2018), American heir and polo player. Peter Busch Orthwein, American heir, businessman, polo player Laura X (born 1940; née Laura Rand Orthwein Jr.), American feminist, human rights activist See also Orthwein Mansion, a historic mansion in St. Louis, Missouri, USA.