Schlissel is a surname. Notable people with the surname include:
Dan Schlissel (born 1970), American record producer and record-label founder (Stand Up! Records, -ismist Recordings) David A. Schlissel, American energy consultant Lillian Schlissel (born 1930), American historian, professor and author Mark Schlissel (born 1957), American academic Yishai Schlissel (born 1975), Israeli homophobic criminal