Muguruza is a Basque surname. Notable people with the surname include:
Fermin Muguruza (born 1963), Spanish rock musician, singer, songwriter, producer, and record label manager Garbiñe Muguruza (born 1993), Spanish-Venezuelan tennis player Joseba Muguruza (born 1994), Spanish footballer Josu Muguruza (1958–1989), Basque-origin Spanish journalist and politician Pedro Muguruza (1893–1952), Spanish architect and Francoist politician