4-Methylcathinone (4-MC), also known as normephedrone, is a stimulant drug of the cathinone group. It is an active metabolite of the better known drug mephedrone (4-methylmethcathinone or 4-MMC).
4-MC is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) similarly to mephedrone. It displays a 2.4-fold selectivity to promote monoamine release via DAT over SERT as opposed to 309-fold selectivity for cathinone. It also releases norepinephrine.
+ Compound Ref Dextroamphetamine 6.6–7.2 5.8–24.8 698–1,765 Dextromethamphetamine 12.3–13.8 8.5–24.5 736–1,292 4-Methylamphetamine 22.2 44.1 53.4 4-Methylmethamphetamine 66.9 41.3 67.4 MDMA 54.1–110 51.2–278 49.6–72 Cathinone 23.6–25.6 34.8–83.1 6,100–7,595 Methcathinone 22–26.1 12.5–49.9 2,592–5,853 Normephedrone 100 220 210 R(+)-Normephedrone 89 150 179 S(–)-Normephedrone 115 391 1,592 Mephedrone 58–62.7 49.1–51 118.3–122 S(–)-Mephedrone 74 61 R(+)-Mephedrone 31 1,470 Methylone 140–270 117–220 234–708 Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Refs:
See also 4-Methylbuphedrone 4-Methylethcathinone
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