Ophain-Bois-Seigneur-Isaac () is a village of Wallonia and a district of the municipality of Braine-l'Alleud, located in the province of Walloon Brabant, Belgium.Dictionnaire des noms de lieux en Wallonie et à Bruxelles, Jean Jacques Jespers, page 456.
It was a municipality in its own right before the fusion of the Belgian municipalities in 1977.
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