Obdulio is a Spanish male given name. Notable people with the given name include:
Obdulio Ávila Mayo (born 1974), Mexican politician Obdulio Diano (1919–2007), Argentine footballer José Obdulio Gaviria, Colombian politician Epifanio Obdulio Guerrero, known as Epy Guerrero, Dominican baseball scout Obdulio "Calulo" Hernández, Honduran footballer Obdulio Morales (1910–1981), Cuban pianist Juan Obdulio Sainz, Deputy National Director of the Argentine National Gendarmerie Obdulio Trasante (born 1960), Uruguayan footballer Obdulio Varela (1917–1996), Uruguayan footballer Obdulio Rogelio Zarza, Argentine boxer