Zeferino is a Portuguese surname and given name. Notable people with the name include:
Given name Zeferino (Portuguese footballer) (born 1978), Portuguese retired footballer João Zeferino da Costa (1840–1915), Brazilian painter and designer Zeferino Martins (born 1985), East Timorese footballer Zeferino Nandayapa (1931–2010), Mexican folk and classical marimba player Zeferino dos Prazeres, São Toméan politician Armando Zeferino Soares (1920–2007), Cape Verdean composer Zeferino Torreblanca (born 1954), Mexican politician and former Governor of Guerrero Zeferino González y Díaz Tuñón (1831–1894), Spanish Dominican theologian, and philosopher, Archbishop of Seville and Cardinal Zeferino Peña Cuéllar, known by his alias "Don Zefe", Mexican suspected drug lord Zeferino Vaz (1908–1981), led the construction, establishment and development of the Unicamp university, State of São Paulo, Brazil
Surname Alfredo Juarez Zeferino (born 2000), Mexican-American farmworker advocate António Zeferino (born 1966), Cape Verdean athlete, specializing in long-distance running, marathon and half marathon Manuel Zeferino (born 1960), Portuguese cyclist
See also Rodovia Professor Zeferino Vaz, a highway in the state of São Paulo, Brazil
Ceferino Zephyrinus