Notable people with the surname Griscom include:
Betsy Ross, probably apocryphal designer of the American flag, born Elizabeth Phoebe Griscom Clement Griscom, American shipping magnate, father of Frances C. Griscom Deborah Griscom Passmore, American botanical illustrator Frances C. Griscom, American amateur golfer, daughter of Clement Griscom John Griscom, American educator Ludlow Griscom, American ornithologist Lloyd Carpenter Griscom, American diplomat Mary Wade Griscom, American physician and medical school professor Nina Griscom, American model, television host, designer, columnist, and businesswoman Tom Griscom, American newspaper editor William Woodnut Griscom, American electrical engineer and founder of the Electro-Dynamic Company