Baldacchino is a surname. Notable people with the surname include:
Clifford Gatt Baldacchino (born 1988), Maltese footballer Francis Baldacchino (1937–2009), Kenyan Roman Catholic bishop Godfrey Baldacchino (born 1960), Maltese-Canadian social scientist Joseph Baldacchino (1894–1974), Maltese archaeologist Peter Baldacchino (born 1960), Maltese-born American Roman Catholic bishop Romilda Baldacchino Zarb, Maltese politician Ruth Baldacchino, (born 1979), LGBT rights activist Ryan Baldacchino (born 1981), English footballer