Hyseni is an Albanian surname. Notable people with the surname include:
Alessio Hyseni (born 1997), Albanian footballer Berat Hyseni (born 1986), Kosovar footballer Erald Hyseni (born 1999), Albanian footballer Haris Hyseni (born 1992), German-Kosovar footballer Klaudio Hyseni (born 1994), Albanian footballer Muhamet Hyseni (born 2001), Kosovan footballer Olti Hyseni (born 2007), Kosovan-Danish footballer Skënder Hyseni (born 1955), Kosovar Albanian politician