Huttenlocher is a surname. Notable people with the surname include:
Anna Huttenlocher, American rheumatologist and physician-scientist Britta Huttenlocher (born 1962), Swiss painter Daniel P. Huttenlocher (born 1959), American computer scientist Janellen Huttenlocher (1932–2016), American psychologist Peter Huttenlocher (1931–2013), American neurologist and neuroscientist Philippe Huttenlocher (born 1942), Swiss opera singer