Spyridon Sotiropoulos () was a Hellenic Army general.
He was born in Patras in about 1859, and enlisted in the infantry as a volunteer on 21 March 1879 (O.S.). He served in the Greco-Turkish War of 1897 and the Balkan Wars of 1912–13, advancing through the ranks. As a monarchist, he was dismissed from the Army in 1917–1920 during the National Schism. He was reinstated with the electoral victory of the monarchist opposition in November 1920, before retiring on 6 October 1921 (O.S.) with the rank of Major General.
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