Gussow is a surname. Notable people with the surname include:
Adam Gussow (born 1958), American musician and writer Alan Gussow (1931–1997), American artist and professor Hans Theodor Güssow (1879-1961), German/Canadian plant pathologist Joan Dye Gussow (1928–2025), American academic and writer Karl Gussow (1843–1907), German artist and professor Margarete Gussow (born 1896), German astronomer Mel Gussow (1933–2005), American theater and movie critic Roy Gussow (1918–2011), American artist
See also Gus Sow (born 1995), English professional footballer